Scanning Electrochemical Microscopy Imaging of DNA Arrays for High Throughput Analysis Applications - Applications of Electrochemistry and Nanotechnology in Biology and Medicine - page 118

(a)

Figure 5. (a) Schematic and a picture of a microfluidic biochip equipped with
microelectronics array. (b) Schematic and a close-view picture for a microelectron-
ics array with installed integrated circuits. The circuit controls each microelectrode
(over 12,000 features) for being addressable individually from an outer electrical
source. Reprinted with permission from Ref. 17, Copyright (2006) American
Chemical Society.

III. SECM AS A DNA SENSOR AND DNA ARRAY

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The astonishing success of scanning tunneling microscopy has
cultivated many variants. SECM is such a technique and can pro-
vide chemical information of the surface. 6, 28 Moreover, SECM
requires the samples to undergo nearly no complex pretreatment,
only having to be transferred into a solution containing re-
dox-active, small molecules or ions (mediator). This makes SECM
uniquely suitable not only for basic physical chemistry purposes
but also to address biological applications including biosensors
and biodevices. SECM can provide detailed information on their