Biomedical Engineering Reference
In-Depth Information
DNA keys
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(d)
100 nm
(e)
(c)
100 nm
(f )
Figure 1.8
(See companion CD for color igure.)
.Examples.of.reconiguration.of.DNA.origami.structures..(a).Box.with.lid;.
the.lid.can.be.opened,.(b).by.addition.of.an.oligonucleotide.“key.”.FRET.dyes.on.the.rim.of.the.box.and.the.lid.
monitor.whether.the.lid.is.open.or.closed..(Reprinted.by.permission.from.Macmillan.Publishers.Ltd..
Nature
,.
Andersen,.E.S..et.al.,.Self-assembly.of.a.nanoscale.DNA.box.with.a.controllable.lid,.459,.73-76,.Copyright.2009.).
Cutting.a.Mobius.strip.is.a.classic.operation.in.topology..Cutting.the.strip.a.third.of.the.way.across.its.breadth.
(c).creates.a.catenated.structure.of.two.linked.rings..(d).shows.how.strand.invasion.was.used.to.cut.the.Mobius.
origami..(e,f).show.AFM.and.EM.images.of.the.resulting.catenated.DNA.rings..(From.Han,.D..et.al.,.Folding.and.
cutting.DNA.into.reconigurable.topological.nanostructures,.
Nat. Nanotechnol.,
.5,.712-717,.2010..Copyright.2011..
Reprinted.with.permission.of.the.AAAS.)
