Biomedical Engineering Reference
In-Depth Information
invasion.was.used.for.cutting.lengthwise.through.the.strip.to.reconigure.it.to.two.cat-
enated.loops.of.DNA!.(Han.et.al..2010).
1.6.5  Hierarchical Assembly of Origami (n-mers and ribbons)
DNA. origami. are. among. the. largest. known. self-assembling. heterogeneous. structures.
(as.opposed.to.homogeneous.structures.like.lipid.vesicles),.but.there.is.a.natural.push.to.scale.
them.up.even.further..For.nanoelectronics.applications,.being.able.to.merge.origami.(with.
attached.circuitry.of.some.kind).with.features.fashioned.by.optical.lithography.is.a.sort.of.
Holy.Grail..The.size.target.of.300-500.nm.is.quite.reasonable,.representing.3-6.individual.
origami..The.use.of.self-assembly.to.put.these.origami.together.is.very.attractive.because.it.
has.the.potential.to.organize.not.just.the.origami.but.their.attached.functional.components..
DNA.origami.have,.therefore,.been.designed.to.undergo.further.self-assembly.by.several.
groups..The.task.is.complicated.by.the.need.to.engineer.out.several.common.defect.types.
(Kim.et.al..2011b),.shown.in.Figure.1.9.for.a.simple.polymer.of.rectangular.origami..Several.
groups.have.used.stepwise.thermal.annealing.of.origami.with.protruding.“sticky.ends”.
to.accomplish.hierarchical.assembly..Figure.1.10.shows.images.from.the.annealing.process.
of. DNA. origami. that. are. designed. to. form. 1D. polymers.. When. samples. are. removed. at.
temperatures.above.50°C.and.quenched.to.room.temperature,.only.individual.origami.are.
Offset
(a)
Up
Up
Down
Down
vs.
Up
Down
or
(b)
vs.
or
(c)
A
B
C
D
(d)
1
0
Figure 1.9
Orientation. defects. for. simple. 2D. rectangular. origami.. (a). Offset. alignment,. (b). relative. orientation/up. and.
down.conigurations,.(c).head-to-tail.orientations,.(d).relative.orientation/1.vs..0.alignment..(Reprinted.by.per-
mission.of.Kim,.K.-N..et.al.,. Soft Matter .7,.4636..Copyright.2011b.)
Search WWH ::




Custom Search