Biomedical Engineering Reference
In-Depth Information
TABLe 14.2
Natural.Polymers.Used.in.Electrospinning.Processes
Resulting Fibers
(Diameter/Elasticity)
Polymers
Biological Relevance
Solvents
References
Collagen
Responsible.for.
providing.tensile.
strength,.cell-matrix.
interactions.and.
matrix-matrix.
interactions
PEO
hexaluoropropanol.
(HFP)
370.kPa,.12.MPa
Native:.50-500.nm
Type.I:.100-5000.nm
Type.II:.20-200.nm
Type.III:.120-600.nm
Type.IV:.100-2000.nm
Huang.et.al..(2001),.
Matthews.et.al..
(2002,.2003),.Barnes.
et.al..(2007),.
Sell.et.al..(2010)
Gelatin
Derivative.of.collagen.
with.structural.
similarity
HFP,.
triluoroethanol.
(TFE),.or.aqueous.
acids.(e.g.,.formic.
acid,.acetic.acid,.
ethyl.acetate,.
and.water)
From.bovine.or.porcine:.
200-500.nm,.8-12.MPa.
(tensile)
From.ish.skin:.
100-800.nm/.
2-4.MPa/120-200.MPa
Li.et.al..(2005),.
Zhang.et.al..(2009),.
Songchotikunpan.
et.al..(2008),.
An.et.al..(2010)
Elastin
Major.component.of.
ECM.in.tissue.
architecture,.provides.
elasticity.to.tissues
HFP
Deionized.water
α-Elastin:.600-3600.nm/.
80-280.MPa
Tropoelastin:.
1400-7400.nm/289.MPa
Elastin-mimetic:.
300-400.nm/.
35.MPa/1.8.GPa
Li.et.al..(2005),.
Sell.et.al..(2010)
Fibronectin
Major.component.of.
ECM,.responsible.for.
cell-matrix.
interaction,.matrix-
matrix.interaction,.
cell.proliferation,.cell.
migration,.and.tissue.
architecture
HFP
80-700.nm/80.MPa
200.nm/7.MPa
Wnek.et.al..(2003),.
McManus.et.al..
(2006),.Carlisle.et.al..
(2009)
Laminin
Critical.ECM.protein.
for.cell.attachment,.
growth.and.survival
HFP
90-300.nm
Neal.et.al..(2009)
Silk.ibroin
Protein.that.forms.the.
ilaments.of.
silkworm.silk
PEO,.formic.acid,.
HFP,.and.water
PEO
Natural:.2-5.μm
6.5-200.nm
400-900.nm
Zarkoob.(1998),.
Zarkoob.et.al..
(2000,.2004),.
Jin.et.al..(2002)
Alginate
Resembles.the.
structure.of.
glycosaminoglycans.
(GAG).that.are.native.
to.connective.tissue.
and.has.the.ability.to.
form.hydrogels
PEO/water
75.nm
5.±.1.MPa.(dry),.7.±.2.MPa.
(with.CaCl
2
.
crosslinking),.and.
2.8.±.1.2.MPa.(wet.with.
CaCl
2
.crosslinking)
Bhattarai.et.al..(2006)
Chitosan
Structurally.similar.to.
GAG.and.degradable.
by.human.enzymes.
(lysozyme)
Dilute.acids.(2.wt%.
acetic.acid),.
concentrated.acids.
(90%.acetic.acid),.
HFP,.PEO
80-180.nm
154.9.±.40.0.MPa.
(as-spun).and.150.8.±.
43.6.MPa.(crosslinked)
Drury.and.Mooney.
(2003),.Duan.et.al..
(2004),.Geng.
et.al..(2005),.
Schiffman.and.
Schauer.(2007)
Phospho-
lipid
Major.component.of.
membranes
Lecithin.solutions
1-5.μm
McKee.et.al..(2006)
