Biomedical Engineering Reference
In-Depth Information
Keywords Aliphatic polyesters
Amphiphilic polymers
Polymer micelles
Self-assembly
Smart materials
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
2 Synthesis of Biodegradable Amphiphilic Polyesters ...................................... 70
2.1 Homopolymers and Random Copolymers . .......................................... 70
2.2 Block Copolymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
2.3 Graft Copolymers and Branched Polymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
3 Microspheres and Nanospheres ............................................................. 80
4 Polymer Micelles ............................................................................ 82
5 Polymersomes . . ............................................................................. 84
6 Nanogels ..................................................................................... 90
7 Supramolecular Biodegradable Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94
8 Biodegradable Stimuli-Responsive Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
8.1 Biodegradable Temperature Responsive Systems ................................... 99
8.2 Biodegradable Injectable Polymers . ................................................. 100
8.3 Biodegradable Shape-Memory Polymers ............................................ 104
9 Conclusion ................................................................................... 106
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Abbreviations
5FU
5-Fluorouracil
Ala
Alanine
Arg
Arginine
Asp
Aspartic acid
ATRP
Atom transfer radical polymerization
BSA
Bovine serum albumin
CD
Cyclodextrin
cDP
Cyclodepsipeptide
CHESG
Cholesterol group-modified enzymatically synthesized glycogen
CHP
Cholesterol-pullulan
CL
e
-Caprolactone
CMC
Critical micelle concentration
Cys
Cysteine
DDS
Drug delivery system
Dex
Dextran
DLA
D
-Lactide
DMAE
Dimethylaminoethyl
DTT
Dithiothreitol
DXO
1,4-Dioxepan-5-one
DXR
Doxorubicin
EP
Ethyl ethylene phosphate
EPR
Enhanced permeability and retention
