Biomedical Engineering Reference
In-Depth Information
Biodegradable Polymeric Assemblies
for Biomedical Materials
Yuichi Ohya, Akihiro Takahashi, and Koji Nagahama
Abstract Recently, self-assembled systems using biodegradable polymers at the
nanometer scale, such as microspheres, nanospheres, polymer micelles, nanogels,
and polymersomes, have attracted much attention especially in biomedical fields.
To construct such self-assembled systems, it is extremely important to have precise
control of intermolecular noncovalent interactions, such as hydrophobic interactions
based on their amphiphilic molecular structures. Biodegradable polymers, especially
aliphatic polyesters such as polylactide, polyglycolide, poly( e -caplolactone) and their
copolymers, have been used as biomedical materials for a long time. This chapter
is mainly focused on aliphatic polyesters and related polymers, and reviews the
synthetic methods for amphiphilic biodegradable polymers containing aliphatic
polyesters as components. Moreover, the application of various types of self-assembly
systems using amphiphilic biodegradable copolymers such as micro- or nanosized
particles (microspheres, nanospheres, polymer micelles, nanogels, polymersomes),
supramolecular physically interlocked systems, and stimuli-responsive systems for
biomedical use such as drug delivery systems are also reviewed.
Y. Ohya ( * )
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and
Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
Organization for Research and Development of Innovative Science and Technology (ORDIST),
Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
e-mail: yohya@kansai-u.ac.jp
A. Takahashi
Organization for Research and Development of Innovative Science and Technology (ORDIST),
Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
K. Nagahama
Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology
(FIRST), Konan University, 7-1-20 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan
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