Biomedical Engineering Reference
In-Depth Information
Table 7.2-1 Hydrolyzable bonds in bioabsorbable macromoecules and the representatives
Bond
Chemical structure
Representative polymers
Ester
PGA, PLA, poly(malic acid)
CO
O
Peptide
Collagen, fibrin, synthetic polypeptides
NC
O
H
Glycoside
HAc, alginate, starch, chitin, chitosan
O
C
C
O
C
C
O
Phosphate
Nucleic acid
O
P
O
O
Anhydride
C
O
C
(
CH
2
)
4
C
O
C
O
O
O
O
O
Carbonate
OCO
O
(
O
C
O
O
CH
2
CH
2
Orthoester
C
O
C
O
O
Carbon-carbon
Poly(isobuty1 cyabiacrylate)
CN
CH
2
C
CO
O
Phosphazene
Polydiaminophosphazene
PN
7.2.2.1.1 Proteins
The major source of naturally derived proteins has been
bovine or porcine connective tissues from peritoneum,
blood vessels, heart valves, and intestine. These connec-
tive tissues have excellent mechanical properties; re-
constructed collagen sponge is incomparable to natural
collagenous tissues with respect to the tensile properties.
Additional drawbacks of naturally derived materials in-
clude possible risks of prion such as bovine spongiform
encephalitis (BSE), immunogenicity of eventually re-
maining cells, their remnants, and biopolymers them-
selves. However, many of natural polymers can promote
