Chemistry Reference
In-Depth Information
Figure 1.11
Experimental concentrations (NMR data) and theoretically-fi tted curves for the
reactions between [Pt(dien)]
+
and DNA: (a) d(TAT
GGT
ACCATA)
2
; (b) d(TAT
GGA
TCCATA)
2
;
(c) d(TAT
GGC
CATA)
2
. Symbols: (
) Pt(dien); (
o
) Pt-G5
. (J. Vinje, J.A.
Parkinson, P.J. Sadler, T. Brown, E. Sletten, Sequence-selective metalation of double-helical
oligodeoxyribonucleotides with PtII, MnII and ZnII ions.
Chem. Eur. J.
, 2003,
9
, 1620-1630.
Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.)
′
and (
∆
) Pt-G3
′
Table 1.2
Rate constants (standard deviations in parentheses)
for reactions of [PtCl(dien)]
+
with DNA oligonucleotides.
pH 5.6, 0.1 M NaClO
4
10
Sequence
k
5
′
(M
−
1
s
−
1
)
k
3
′
(M
−
1
s
−
1
)
-GGTA-
(a)
4.3 (6)
0.5 (1)
-GGAT-
(a)
4.0 (6)
3.4 (5)
-GGCC-
(b)
7.6 (6)
(c)
Temperature: (a) 288 K; (b) 298 K; (c) Negligible 3
′
-G platination.
