Chemistry Reference
In-Depth Information
15.
Maizels, N.; Dynamic roles for G4 DNA in the biology of eukaryotic cells;
Nat. Struct.
Mol. Biol.
, 2006 ,
13
, 1055 - 1059 .
Todd , A.K. ; Johnston , M. ; Neidle , S.; Highly prevalent putative quadruplex sequence
motifs in human DNA;
Nucleic Acids Res.
, 2005 ,
33
, 2901 - 2907 .
Huppert , J.L. ; Balasubramanian, S.; Prevalence of quadruplexes in the human genome;
Nucleic Acids Res.
, 2005 ,
33
, 2908 - 2916 .
Kostadinov , R. ; Malhotra , N. ; Viotti , M. ; Shine , R. ; D ' Antonio , L. ; Bagga , P. ; GRSDB:
a database of quadruplex forming G-rich sequences in alternatively processed mam-
malian pre - mRNA sequences ;
Nucleic Acids Res.
, 2006 ,
34
, D 119 - D 124 .
Rawal , P. ; Kummarasetti , V.B.R. ; Ravindran , J. ; Kumar , N. ; Halder , K. ; Sharma , R. ,
et al.
;
Genome-wide prediction of G4 DNA as regulatory motifs: role in
Escherichia coli
global
regulation ;
Genome Res.
, 2006 ,
16
, 644 - 655 .
Eddy , J. ; Maizels , N. ; Gene function correlates with potential for G4 DNA formation in
the human genome;
Nucleic Acids Res.
, 2006 ,
34
, 3887 - 3896 .
Huppert , J.L. ; Balasubramanian , S. ; G - quadruplexes in promoters throughout the human
genome ;
Nucleic Acids Res.
2007 ,
35
, 406 - 413 .
Han , H.Y. ; Hurley , L.H. ; G - quadruplex DNA: a potential target for anti - cancer drug
design ;
Trends Pharmacol. Sci.
, 2000 ,
21
, 136 - 142 .
Read , M. ; Harrison , R.J. ; Romagnoli , B. ; Tanious , F.A. ; Gowan , S.H. ; Reszka , A.P. ,
et al.
;
Structure-based design of selective and potent G quadruplex- mediated telomerase
inhibitors ;
Proc. Natl. Acad. Sci. USA
, 2001 ,
98
, 4844 - 4849 .
Neidle , S. ; Parkinson , G.; Telomere maintenance as a target for anticancer drug
discovery ;
Nat. Rev. Drug Discov.
, 2002 ,
1
, 383 - 393 .
Mergny , J.L. ; Riou , J.F. ; Mailliet , P. ; Teulade - Fichou , M.P. ; Gilson , E. ; Natural and phar-
macological regulation of telomerase;
Nucleic Acids Res.
, 2002 ,
30
, 839 - 865 .
Harrison , R.J. ; Cuesta , J. ; Chessari , G. ; Read , M.A. ; Basra , S.K. ; Reszka , A.P. ,
et al.
;
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors;
J. Med. Chem.
, 2003 ,
46
, 4463 - 4476 .
Incles , C.M. ; Schultes , C.M. ; Kempski , H. ; Koehler , H. ; Kelland , L.R. ; Neidle , S. ; A G -
quadruplex telomere targeting agent produces p16-associated senescence and chromo-
somal fusions in human prostate cancer cells;
Mol. Cancer Ther.
, 2004 ,
3
, 1201 - 1206 .
Ou , T.M. ; Lu , Y.J. ; Zhang , C. ; Huang , Z.S. ; Wang , X.D. ; Tan , J.H. ,
et al.
; Stabilization of
G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives;
J. Med. Chem.
2007 ,
50
, 1465 - 1474 .
Kelland, L.R.; Overcoming the immortality of tumour cells by telomere and telomerase
based cancer therapeutics - current status and future prospects;
Eur. J. Cancer
, 2005 ,
41
,
971 - 979 .
Parkinson , G.N. ; Ghosh , R. ; Neidle , S. ; Structural basis for binding of porphyrin to human
telomeres ;
Biochemistry
, 2007 ,
46
, 2390 - 2397 .
White , E.W. ; Tanious , F. ; Ismail , M.A. ; Reszka , A.P. ; Neidle , S. ; Boykin , D.W. ,
et al.
;
Structure - specifi c recognition of quadruplex DNA by organic cations: Infl uence of
shape, substituents and charge;
Biophys. Chem.
, 2007 ,
126
, 140 - 153 .
Reed , J.E. ; Arnal , A.A. ; Neidle , S. ; Vilar , R. ; Stabilization of G -quadruplex DNA and
inhibition of telomerase activity by square- planar nickel(II) complexes ;
J. Am. Chem.
Soc.
, 2006 ,
128
, 5992 - 5993 .
Franceschin , M. ; Rossetti , L. ; D ' Ambrosio , A. ; Schirripa , S. ; Bianco , A. ; Ortaggi , G. ,
et al.
; Natural and synthetic G-quadruplex interactive berberine derivatives;
Bioorg.
Med. Chem. Lett.
, 2006 ,
16
, 1707 - 1711 .
Moore , M.J.B. ; Cuenca , F. ; Searcey , M. ; Neidle , S. ; Synthesis of distamycin A polyamides
targeting G - quadruplex DNA ;
Org. Biomol. Chem.
, 2006 ,
4
, 3479 - 3488 .
Le Sann , C. ; Baron , A. ; Mann , J. ; van den
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
Berg , H. ; Gunaratnam , M. ; Neidle , S. ; New
mustard - linked 2 - aryl - bis - benzimidazoles with anti - proliferative activity ;
Org. Biomol.
Chem.
, 2006 ,
4
, 1305 - 1312 .
Moore , M.J.B. ; Schultes , C.M. ;
36.
Tanious , F.A. ,
et al.
; Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of
Cuesta , J. ; Cuenca , F. ; Gunaratnam , M. ;
