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other factors, including the energy of dehydration and/or coordination number,
which must be considered.
Thermodynamic stability data and cation competition experiments consistently
show that K
+
ions have an optimal balance between favourable coordination within
a G-quadruplex and not too unfavourable free energy of dehydration. At the other
end of this spectrum are Cs
+
and Li
+
ions. It appears that these cations are not
favourable for G-quadruplex stabilization because Cs
+
is too large for optimal
coordination by G-quartets, whereas the free energy required for Li
+
dehydration
is much higher than for the other alkali metal ions.
Acknowledgements
Financial support from Slovenian Research Agency (ARRS) and the Ministry of
Higher Education, Science and Technology of the Republic of Slovenia (Grant Nos.
P1-0242 and J1-0986) is gratefully acknowledged.
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