Biomedical Engineering Reference
In-Depth Information
Chapter 5a
Scaffold-Based Myocardial Patches
Tadashi Sasagawa
Institute of Advanced Biomedical Engineering and Science,
Tokyo Women's Medical University, 8-1 Kawada-cho,
Shinjuku-ku, Tokyo 162-8666, Japan
sasagawa.tadashi@twmu.ac.jp
5a.1 Introduction
Heart failure (HF) is a leading cause of death worldwide. Cardiac
tissue engineering aims to enhance cardiac function in patients with
heart disease by providing suitable implantable replacement tissues.
The creation of functional three-dimensional (3D) cardiac tissue
constructs to repair damaged or diseased myocardium requires
growth factors, reparative cells, and biomaterial scaffolds [1]. Various
groups have reported fabrication methods of a 3D cardiac patch
using several different types of scaffolds, including biodegradable
polymer-based sponges/meshes, hydrogels, and decellularized
tissue matrices, for cardiac tissue repair. This chapter provides an
overview of the research on scaffold-based cardiac patches for the
improvement of cardiac function using animal models of HF.
