Biology Reference
In-Depth Information
U1_in
TIA_intron_bdg
ASFp_ex_in
U1_CBC_bdg
5ss_in
Prp5_in
BPS_in
3ss_in
U2AF65_in
U2AF35_in
U2A_in
U2B_in
PPT_in
3ss
U2AF35
U2AF65
ASFp_ex
5ss
U1_CBC
TIA_int
Prp5
BPS
U2A
U2B
5ss
U1
U2AF
U2
SF1_in
PPT_inhib
12S_U2_core
PPT
U1
U2AF_dim
SF3b_in
12S_U2_core_in
U1_CBC_5ss_bdg
U1_5ss_bdg
SF1_BPS_bdg
ASFp_U170K_bdg
U1C_TIA1_bdg2
5ss
U1
U1_Prp5_U2_bdg
SF1
SF3b
15S_U2_matur
U2AF35_3ss_bdg
ATP
ADP
U1C_TIA1_bdg1
SF1_BPS
U1_5ss
17S_U2_matur1
ASFp_U1_5ss
SF3a_in
15S_U2
U1_5ss
SF3a
SC35
SF1_BPS
U2AF_PPT_3ss
FBP11_in
TIA_int
SF1_U2AF_bdg
SF3b125
U1_SC35_SF1_bdg
5ss
SF1_U2AF
5ss
SPF30_in
SPF30
FBP11
U1_5ss
SF3b155_U2AF65_bdg
17S_U2_matur2
U1_SC35_SF1
SF1_U2AF
hPrp43
U1_Prp5_U2
U1_5ss_U2_U2AF_bdg
U2
SC35
SF1_BPS
ATP
ADP
SPF45_in
SC35_in
SC35
U1_indep_5ss_act
U1_SF1_bdg
U2
SPF45
U170K_U2AF35_bdg
U2_PPT
SF3a
U2_SC35_bdg
U2AF_SC35_5ss
SF3a60
U1_SC35_U2
U1U2_bridge
unwind1_U2_stl2
U1_SF1
Prp5
ATP
unwind2_U2_stl2
U2AF_PPT_3ss
ATP
Prp5
SF3a60
ADP
U1_SF1_U2AF_bdg
U1U2_remod
SF3a60
UAP56
ADP
UAP56_in
U1_SF1_U2AF
unwind3_U2_stl2
UAP56_U2AF65_bdg2
U2_remod1
U4_in
U6_in
U2_remod2
ATP
UAP56
UAP56_U2AF65_bdg1
SF1_out
SF1
U1U2_UAP56_ass
U4
U6
U2_BPS_bdg2
U2_UAP56_ass
UAP56
Prp24
SF1
Prp31
U2AF
SF1
U2AF
Prp24_in
U2_BPS_bdg3
ADP
U4_U6_bdg
SF1
U2AF
U2_UAP56_ass
U2_BPS_bdg1
U4U6_complex
U2_UAP56_ass
U2_BPS
U1U2_BPS_bdg
U1U2_BPS
20S_U5
A Complex
Prp38
U5_in
Prp5
Prp28
ATP
ADP
ATP
ADP
U4U6_U5_bdg
Prp5_out
U1C_diss
hPrp6_in
CypH_trimer_in
hPrp6
CypH_trimer
U5_Prp8
U4U6U5_conf1
U1C
hSad1
ADP
ATP
hSad1_in
hLin1
U1_5ss_destab
hSnu66_in
tris_27K_in
U4U6U5_stab
hSnu66
tris_27K
U4U6U5_conf3
hDib1
U4U6U5_conf3
hDib1_out
hDib1
U4U6U5_conf2
Prp28
U6_5ss_bdg2
U1_out
Prp28_out
GTP
U1
Prp28
GTP_in
U6_5ss_bdg1
Prp38
U4_out
Snu114_Brr2_act
U4
Prp38
U4
GDP_out
U2U6U5_5ss
GDP
NTC_form
Brr2_ass
Lsm
NTC_heteromer
Prp3
ATP
CypH_trimer
B_compl_act
Prp19
Prp19_in
CypH_trimer_out
14S_NTC_Prp19
Prp19_stab
Prp19
U4U6_uwd
SKIP_in
Prp31
ADP
SKIP
U2_3ss_U6_5ss_U5
U4U6U5_conf3
HSP73_in
DDX35_in
ASF_SF2_out
SC35_out
Spp2
ATP
Spp2_in
Spp2_Prp2_sact
1st_catal_step
ASF_SF2
SC35
ATP
ADP
Prp2_ass
HSP73
DDX35
Prp2_in
ADP
Prp2
Prp16
U2_3ss_U6_5m_discard
discard_pathway
U2_3ss_U6_5ss_U5_remod
U2_3ss_U6_5ssfree_U5
premature_ATP_hydrol
SF3b14b_out
SF3b49_out
ADP
ATP
SF3b14b
SF3b14a_out
SF3b49
SF3b14a
SF3b10_out
U2_5ss_U6_U5_conf1
SF3b10
Prp16_remod_step
hPrp6_out
Spp382_in
U2_5ss_U6_U5_conf2
Prp16
hPrp6
ATP
ADP
Prp18_in
ATP
Spp382
Prp18
hPrp43
Prp22
post_splsom_complex
Prp22_in
U2U6U5_3ss_remod
Prp17_in
Prp43_in
intron_release
Prp17
Prp43_ass
Spp382_hPrp43_act
Slu7_in
Slu7
ADP
U2U6_lariat
U2U6U5_3ss
35S_U5
Prp28
hDib1
GTP
U6
20S_U5
2nd_catal_step
U6_out
U2_release
35S_U5_conv
20S_U5_out
GDP
spliced_mRNA
U2
intron
SKIP_out
14S_NTC_Prp19_out
SKIP
14S_NTC_Prp19
mRNA_out
U2_out
5ss_out
Fig. 8. Pathway of spliceosome assembly. The red transitions belong to T-invariant 13 (see Supplementary Table S2) and
describe a scenario of E-complex assembly, which is one of several redundant partial pathways of spliceosome assembly. Here,
the 5' splice site is recognized via an U1 snRNP independent pathway. (Colours are visible in the online version of the article
at
www.iospress.nl
.)
