Minimum Reactants Required for Synthesis of Skin and Peripheral Nerves; Extension to Tissues of Other Organs - Tissue and Organ Regeneration in Adults - page 189

Table 7.2 (continued)

No. Reactants Reaction conditions and structure of

product

References

N8 SC → No BM Schwann cells cultured without neurons;

BM components, but not BM, synthesized

Bunge et al. 1982; Carey et al. 1983;
McGarvey et al. 1984; Clark and
Bunge 1989; Obremski et al. 1993

N9 AX + SC + LA → MAX · BM Schwann cells cultured with neurons and

laminin; BM synthesized

Eldridge et al. 1989

N10 Schwann cells with collagen matrix

inside silicone tube bridging gap between
transected stumps in absence of axons;
BM synthesized on Schwann cell surface

Ikeda et al. 1989

in vivo →

BM

SC + COM

N11 SC + FB → BM Schwann cells cultured with fibroblasts;

BM synthesized

Obremski et al. 1993

N12 SC + LA → BM Laminin added to Schwann cell culture;

BM synthesized in absence of myelin
sheath

Obremski et al. 1993

C. Endoneurium (ED)
N13 AX + SC → No ED Schwann cells cultured with neurons; no

endoneurium synthesized

Bunge et al. 1980

N14 Silicone tube bridge; functional peri-

neurium synthesized; no physiological
endoneurial vasculature synthesized

Azzam et al. 1991 in vivo →

MAX · BM · ED(?) · PN

SITB

D. Perineurium (PN)
N15 AX + SC → No PN Schwann cells cultured with neurons; no

perineurium synthesized

Bunge et al. 1980

N16 AX + FB → No PN Schwann cells cultured with fibroblasts;

no perineurium synthesized

Williams et al. 1982

N17 AX + SC + FB → MAX · BM · ED(?) · PN(?) Schwann cells cultured with neurons

and fibroblasts; perineurial-like cells

Williams et al. 1982; Bunge et al.
1989