Biomedical Engineering Reference
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(a)
PEG-silane/
RITC-APTES
Ta(OEt)
5
Purification
5 min
24 h
Fe
3
O
4
/TaO
x
-Me
Microemulsion (ME)
Fe
3
O
4
/TaO
x
-RITC-PEG-ME
Fe
3
O
4
/TaO
x
-RITC-PEG
(b)
i
ii
TV
iii
iv
Li
Tu
Sp
(c)
i
ii
iii
iv
fIgure 2.9
(a) Scheme for the synthesis and surface modification of Fe
3
O
4
/TaO
x
core-
shell NPs. (b)
In vivo
x-ray cT images and (c)
in vivo T
2
-weighted MR images of a rat bearing
a MaT B III tumor (i) before and (ii) 1 h, (iii) 2 h, and (iv) 24 h after the injection of Fe
3
O
4
/TaO
x
core-shell NPs. TV, li, Tu, and Sp in cT images indicate the tumor-associated vessel, liver,
tumor, and spleen, respectively. (Reprinted with permission from Ref. [55]. © american
chemical Society.)
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