Nanoparticles for Bioimaging: Analytical Characterization and Measurements - Nanotechnology for Biomedical Imaging and Diagnostics - page 181

figure 6.26 Principle of measuring size of a nanoparticle with flow cytometry. Smaller
particles produce less front scattering.
most common configuration)—are recorded. The magnitude of the forward scatter is
to the first approximation proportional to the size of the particle. Small particles will
produce small forward scattering, while large particles produce larger scattering
(fig. 6.26). Particles as small as 58 nm can be detected, allowing to distinguish the
differences in the size distributions between nanoparticles even if the difference in
diameter was only 25 nm [107]. flow cytometry has thus been utilized for the
characterization of gold nanorods, viral nanoparticles [108], and quantum dots.
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