Biomedical Engineering Reference
In-Depth Information
Fig. 3 A three hydrophobic
point pharmacophore model
for
K
v
1.5
blockers
pharmacophore model and biphenyl derivatives: the central phenyl moiety of
compound 33 matches the middle hydrophobic center, and both ends of the side
chains correspond to the remaining hydrophobic centers of the model.
N
N
CH
3
O
O
O
H
31
O
CH
3
O
O
S
H
H
CH
3
Cl
Cl
32
O
Cl
N
H
NH
S
O
O
Cl
33
