Biomedical Engineering Reference
In-Depth Information
CH
2
HO
H
N
N
H
3
C
S
CH
3
H
O
O
O
H
3
C
H
CH
3
OH
N
Quinidine
Sotalol
N
H
3
C
S
CH
3
O
O
N
O
O
O
S
H
CH
3
Dofetilide
N
H
3
C
O
S
O
CH
3
N
OH
CH
3
Ibutilide
F
O
F
OH
N
F
O
H
CH
3
F
F
O
O
F
O
NH
Propafenone
Flecainide
3.2 Multiple Ion Channel Blockers
During recent years, some multimechanism blockers were also applied in clinical
treatment of arrhythmic diseases. The overall efficacy of these agents on several
electronic current in cardiac myocytes may expand their therapy spectrum,
although some detailed mechanisms are still controversial.
Amiodarone is approved by the Food and Drug Administration for the treatment
of lethal ventricular arrhythmias but not for the management of atrial diseases.
