Functional Mesoporous Silica Nanoparticles with a Core-Shell Structure for Controllable Drug Delivery - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 52

(a)

OH

Hydrophobic
core

Shell

OH

OH
OH

Hydrophobic
core

Hollow mesoporous
silica

Route A

OH

OH

Hydrophobic
core

Core

OH
OH

SiO 2

sSiO 2 @mSiO 2

Route B

OH

Hydrophobic
core OH

OH
OH
OH

Hydrophobic
core

Shell Hydrophobic

core

Hollow mesoporous
silica

Rattle-type
structure

(c)

(b)

0.5 µm 100 nm

FIGURE 3.2
(a) Schematics of the formation of hollow/rattle-type mesoporous silica spheres. Route A rep-
resents the selective-etching procedure in Na 2 CO 3 solution and Route B for that in ammo-
nia solution under hydrothermal treatment. (b) TEM image of HMS nanoparticles obtained
by treating sSiO 2 @mSiO 2 in 0.6 M Na 2 CO 3 solution at 80°C for 0.5 h. (c) HMS nanoparticles
obtained by treating sSiO2@mSiO2 in 0.24 M ammonia solution at 150°C for 24 h. (Reprinted
with permission from Chen Y., Chen H., Guo L., et al. ACS Nano 4: 529-539, 2010, Copyright
2009, American Chemical Society.)