Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 12

TABLE 1.2
Drug/Growth Factor Category for MBG Materials

Drug/Growth Factor
Category MBG Materials Reference

Particles Gentamicin Xia and Chang 2006, 2008

Ibuprofen Li, Wang, Hua, et al. 2008; Lin et al. 2009; Fan,

Huang, et al. 2011

Ipriflavone Lopez-Noriega et al. 2010

Disks Tetracycline Zhao, Yan, et al. 2008

Metoclopramide Zhao, Loo, et al. 2008

Phenanthrene Lin et al. 2010

Spheres Triclosan Arcos et al. 2009

Ibuprofen Kang et al. 2011

Ampicillin Fan, Wu, et al. 2011

Bovine serum albumin Wu, Zhang, Ke, et al. 2010

Fibers Gentamicin Hong, Chen, Jing, Fan, Guo, et al. 2010; Hong,

Chen, Jing, Fan, Gu, et al. 2010

Scaffolds Gentamicin Zhu and Kaskel 2009; Zhu, Li, et al. 2011; Zhu,

Zhang, Wu, et al. 2011

Dexamethasone Wu, Zhang, Zhu, et al. 2010; Wu, Fan, Gelinsky,

et al. 2011; Wu, Fan, Zhu, et al. 2011; Wu, Luo, et
al. 2011; Wu, Miron, et al. 2011

VEGF* Wu et al., forthcoming

BMP** Dai et al. 2011

Composites Gentamicin/naproxen Xia et al. 2008; Li, Wang, et al. 2009; Zhu, Zhang,

He, et al. 2011

Dexamethasone Wu, Ramaswamy, et al. 2009; Wu, Zhu, et al. 2010

Source: Wu, C., and Chang, J., 2012. Mesoporous bioactive glasses: Structure characteristics,
drug/growth factor delivery and bone regeneration application. Interface Focus 2:
292-306.
* VEGF, vascular endothelial growth factor.
** BMP, bone morphogenetic protein.

efficiency and decrease of drug release rate and burst effect. The possible
reason is that the drugs may be chelated with calcium on the pore wall,
which makes it difficult to be released (Zhao, Yan, et al. 2008). It is found
that 58S MBG has slower release kinetics than 77S MBG, indicating that CaO
contents in MBG plays an important role in modulating the drug release
(Xia and Chang 2006). Besides the composition, the mesoporous structure of
MBG is of great importance to influence the drug delivery. Zhao, Loo, et al.
(2008) used different surfactants (P123 and F127) to prepare MBG and found
that P123-MBG had higher pore volume and surface area than F127-MBG.
The higher pore volume and surface area of P123-MBG lead to significantly
higher drug-loading efficiency (47.3%) compared to that of F127-MBG (16.6%).
These studies suggest that MBG is an excellent drug and growth factor deliv-
ery system (Xia and Chang 2006; Wu, Miron, et al. 2011; Dai et al. 2011). The