Biomedical Engineering Reference
In-Depth Information
(a)
(b)
FIGURE 1.5
(a) MBG/silk composite scaffolds with (b) excellent apatite-mineralization ability in SBF.
1.3 Drug and Growth Factor Delivery of MBG
1.3.1 Controllable Delivery of Drug and Growth Factor in MBG
One of the significant advantages of MBG materials is that they possess higher
specific surface area and pore volume than conventional bioactive glasses,
which makes them useful for drug delivery. In the past several years, MBG
with different material forms have been used for the study of drug delivery.
Table 1.2 summarizes the drug and growth factor category for the different
forms of MBG (Wu and Chang 2012). It can be seen that different categories
of drug and growth factors (vascular endothelial growth factor [VEGF] and
bone morphogenetic protein [BMP]) can be efficiently loaded and released in
MBG particles, disks, spheres, fibers, scaffolds, and composites. The loading
efficiency of drug and growth factors in MBG is significantly higher than
that in conventional bioactive glasses (Xia and Chang 2006; Zhu and Kaskel
2009). The drug release kinetic in MBG is lower than that in conventional
bioactive glasses. The loading efficiency and release kinetic can be controlled
by adjusting the composition of MBG. Zhao, Yan, et al. (2008) found that
the increase of CaO content in the MBG led to the enhancement of loading
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