Biomedical Engineering Reference
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(a)
(b)
100 nm
FIGURE 1.2
(a) Large-size MBG beads with a (b) well-ordered mesoporous channel structure.
range of 2 to 5 µm, and a mesoporous shell (500 nm) can be prepared by
a sol-gel method using polyethylene glycol (PEG) as a template (Lei, Chen,
Wang, and Zhao 2009). Zhao et al . (2010) prepared MBG microsphere with
high P 2 O 5 contents (up to 15%), and an approximate size of 4 to 5 µm, by
using cosurfactants of P123 and cetyltrimethylammonium bromide (CTAB).
Luminescent calcium silicate MBG microspheres with a diameter of 400 nm
and the mesopore size of 6 nm were recently developed by Kang et al. (2011).
Yun et al. (2010) produced MBG nanospheres with both a large specific sur-
face area (1040 m 2 /g) and pore volume (1.54 cm 3 /g), while the size of MBG
nanospheres can be further controlled over a diameter range of 20 to 200 nm
by the addition of various amounts of CaO. Novel porous MBG nanospheres
(80-150 nm) were prepared by a hydrothermal method, which had excellent
mineralization ability (Wu and Chang 2012).
MBG can also be prepared as 3D porous scaffolds for bone tissue engi-
neering and drug-delivery applications (Wu and Chang 2012). Currently,
there are three methods to prepare MBG scaffolds. The first MBG scaffold
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