Biomedical Engineering Reference
In-Depth Information
5
Biomimetic Preparation and
Biominerali
zation of Bioceramics
Zhongru Gou, Ahmed Ballo, and Wei Xia
CONTENTS
5.1 Introduction .................................................................................................. 117
5.2 Biomimetic Preparation of Bioceramics .................................................... 119
5.2.1 Transformation and Replication of Biological Origin into
Calcium Phosphate Ceramics ...................................................... 119
5.2.2 Volatile Additives to Create Macropore Bioceramics ................. 121
5.2.3 Nanocrystalline Calcium Phosphate Bioceramics ...................... 124
5.2.4 Trace Element Incorporating into Calcium Phosphate
Bioceramics ..................................................................................... 125
5.2.5 Inorganic-Organic Composite Biomimetic Bioceramics ............ 127
5.3 Biomineralization of Bioceramics .............................................................. 127
5.3.1 Biomineralization of Oxide Bioceramics ...................................... 130
5.3.2 Biomineralization of Silicate- and Aluminate-Based
Bioceramics ..................................................................................... 131
5.3.3 Biomineralization of Phosphate-Based Bioceramics ................... 133
5.4
In Vitro
and
In Vivo
Reaction of Biomimetic and Biomineralized
Bioceramics ................................................................................................. 133
5.4.1 Clinical Background ........................................................................ 133
5.4.2 Biological Performance of Biomimetic and Biomineralized
Bioceramics ..................................................................................... 135
5.5 Conclusion and Comments ........................................................................ 138
References ............................................................................................................. 138
5.1 Introduction
Bioceramics are usually polycrystalline inorganic materials used in biomedi-
cal application, such as hard tissue repair and regeneration, drug delivery,
and implant coatings. In this chapter, the concept of “bioceramic” is extended.
Bioglass and glass-ceramic are also included as bioceramics. Table 5.1 sum-
marizes various bioceramics that are acceptable and widely studied.
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