Biomedical Engineering Reference
In-Depth Information
TABLE 8.1
International Classification of Enzymes: Code Numbers (EC 1st Digit, 2nd Digit, 3rd Digit,
4th Digit) and Types of Reactions Catalyzed
1st Digit (Class)
2nd Digit
3rd Digit
4th
1. Oxidoreductases
Transfer of hydrogen or oxygen
atoms or electrons from one
substrate to another: oxidases or
dehydrogenases
Acceptor of hydrogen
or electron
1 NAD
þ
or NADP
þ
or
peroxidase
2 Cytochrome or heme
protein
3O
2
4S
e
S
5 Quinone or similar
6 Nitrogenous group
7Iron
e
sulfur
e
protein
8 Flavin
11 Incorporating two O
12 Incorporating one O
98 Other, known
99 Other
Donor of hydrogen or electron
1 Alcohol
2 Aldehyde or ketone
3 Alkene,
e
CH
]
CH
e
4 Primary amine: CH
e
NH
2
5 Secondary amine: CH
e
NH
e
6 NADH or NADPH
7 Nitrogenous compound
8 Sulfur group
9 Heme group
10 Diphenols or related
11 Peroxide
12 Hydrogen
13 Single donor with O
2
14 Paired donors, with O
2
15 Acting on superoxide
16 Oxidizing metal ion
17 Acting on CH or CH
2
groups
18 Iron
e
sulfur
e
protein
19 Reduced flavodoxin
20 Phosphorous or arsenic
21 on XH and YH to form XY
97 Oxidoreductases
98 Other, using H
2
as reductant
99 Other, using O
2
as oxidant
2. Transferases
Group transfer excluding hydrogen
or oxygen:
AX
General type of group
1 1-Carbon group
2 Aldehyde or ketone
3 Acyl group
e
COR
4 Glycosyl group
5 Alkyl or aryl, other than methyl
6 Nitrogenous groups
7 Phosphate group
8 Sulfur-containing groups
9 Selenium-containing groups
Nature of group
transferred
þ
B
BX
þ
A
/
3. Hydrolases
Catalyzes hydrolysis:
A
e
X
Type of bond hydrolyzed
1 Ester
2 Glycosylases
3 Ether
4 Peptide
5C
e
N bonds other than peptides
6 Acid anhydrides
7C
e
C
8 Halide
9 Phosphorus
e
nitrogen
10 S
e
N
11 C
e
phosphorus
12 S
e
S
13 S
e
S
þ
H
2
O
X
e
OH
þ
HA
/
(Continued)
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