Phase-Sensitive Optical Coherence Microscopy (OCM) - Biomedical Optical Phase Microscopy and Nanoscopy - page 269

speeds, allowing study of dynamic biologic processes. Further advantages of the method
include robustness, system stability due to common-path design, transportability, and the
minor radiation exposure, which give this technology great potential for clinical
applications.

SD-OCM and SS-OCM methods are much more common in phase OCM applications since
TD-OCM is more likely to have higher phase noise. In addition, the SD-OCM can achieve
higher acquisition rates than TD-OCM, an advantage which is vital in studying dynamic
biological processes. With the development of fast scanning-wavelength lasers, SS-OCM
can be also used to study cell activity with high phase stability and high SNR. Single-point
imaging inherently has a higher SNR than the full-field or line-scan systems, and so it is
ideal in measuring very small phase changes, in cases where the two-dimensional spatial
changes are less of interest than the temporal changes in the point measured. Determining
the central wavelength to be used also is important as using longer wavelengths means
obtaining reduced axial and lateral resolution but, on the other hand, usually means obtaining
higher penetration depth.

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