Biomedical Engineering Reference
In-Depth Information
Table 5
SLN as nanocarrier for siRNA/miRNA delivery
S. No
SLN composition
Target gene (SiRNA/miRNA)
Cell lines/Animal models
References
Cholesteryloleate, glyceryltrioleate (triglyceride),
and Cholesterol, DOPE, 3
_
-[
N
-(
N
′,
N
′-
dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)
VEGF siRNA
PC3 cells (human prostate
cancer cell line)
GFP overexpressing
MDAMB435 cells (human
breast cancer cells)
Kim et al. (2008)
1.
2.
Cholesterol hydrochloride (Chol), L-
ʱ
-dioleoyl
phosphatidylethanolamine (DOPE), and 3
ʲ
-[
N
-
(
N
′,
N
′dimethylaminoethane)-carbamoyl]-cholesterol
(DC-Chol), Cholesteryl oleate and glyceryltrioleate
c-met siRNA
U-87MG human
Glioblastoma cells
U-87MG tumor-bearing
mouse
Rodrígueza et al. (2010)
3.
Tristearin, soybean lecithin, DSPE-PEG
K6a_513a.12 siRNA,
Accell CBL3 siRNA
293FT cells
CD1 mice
Doktorovova et al. (2011)
Linear PEI (2500 Da), Tripalmitin and triolein,
DSPE-PEG-folate, cholesterol
Survivin-siRNA,
PC3 cell line (human
prostate cancer)
Male athymic mice
Xue et al. (2011)
4.
Glyceryltrioleate, 1,2-diphytanoylsn-glycero
-3-phosphatidylethanolamine (DPhPE), DC-Chol,
EDOPC, mPEG-DSPE
Human MCL1-speciic
siRNA luciferase-speciic
siRNA
Human epithelial carcinoma
KB cells and MDA-MB-231
cells
KB cell-xenografted mice
Yu et al. (2012)
5.
6.
Glycerylmonostearate (GMS), soy
phosphatidylcholine, cholesterol (Chol),
Dimethyldioctadecylammonium bromide (DDAB)
Anti-miR-21 (AMO)
A549 cells
Shi et al. (2012)
Cholesteryloleate, triolein, Cholesterol
hydrochloride (Chol), DOPE, DC-Chol,
DSPE-PEG 2k
Connective tissue growth
factor siRNA (siCTGF)
HepG2.2.15 cells
(Hepatocellular carcinoma
(HepG2 cell) and HBV)
Sprague Dawley (SD) rats
Kong et al. (2013)
7.
