Biomedical Engineering Reference
In-Depth Information
and show high toxicity against cancerous cells. Later, cisplatin (CDDP)-loaded
gelatin/poly(acrylic acid) (GEL-PAA) NPs were prepared by Ding et al. (2012).
They studied the tumor accumulation and targeting efficiency of GEL-PAA by
in vivo NIRF imaging and ex vivo gamma scintillation counting analyses as
shown in Fig.
24
. Moreover the NPs get penetrated into the tumor after their
Fig. 24 a
In vivo NIRF images of H22 tumor-bearing mice after i.v. injection of NIR-797 labeled
and CDDP-loaded GEL-PAA nanoparticles. The
arrow
indicates the location of tumor tissue.
b
The fluorescence intensity for the region of interest (tumor) was recorded as total photon counts per
tumor. Adapted from Ding et al., with permission from American Chemical Society. Copyright 2012
