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Owen DR, Walker JK, Jon Jacobsen E, Freskos JN, Hughes RO, Brown DL, Bell AS, Brown DG,
Phillips C, Mischke BV, Molyneaux JM, Fobian YM, Heasley SE, Moon JB, Stallings WC,
Joseph Rogier D, Fox DN, Palmer MJ, Ringer T, Rodriquez-Lens M, Cubbage JW, Blevis-Bal
RM, Benson AG, Acker BA, Maddux TM, Tollefson MB, Bond BR, Macinnes A, Yu Y (2009)
Identification, synthesis and SAR of amino substituted pyrido[3, 2b]pyrazinones as potent and
selective PDE5 inhibitors. Bioorg Med Chem Lett 19:4088-4091
Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS (2009) Mechanism for the allosteric
regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length
construct. Proc Natl Acad Sci USA 106:18225-18230
Penmatsa H, Zhang W, Yarlagadda S, Li C, Conoley VG, Yue J, Bahouth SW, Buddington RK,
Zhang G, Nelson DJ, Sonecha MD, Manganiello V, Wine JJ, Naren AP (2010) Compartmen-
talized cyclic adenosine 3 0 ,5 0 -monophosphate at the plasma membrane clusters PDE3A and
cystic fibrosis transmembrane conductance regulator into microdomains. Mol Biol Cell
21:1097-1110
Poppe H, Rybalkin SD, Rehmann H, Hinds TR, Tang XB, Christensen AE, Schwede F, Genieser
HG, Bos JL, Doskeland SO, Beavo JA, Butt E (2008) Cyclic nucleotide analogs as probes of
signaling pathways. Nat Methods 5:277-278
PuxedduE,UhartM,LiCC,AhmadF,Pacheco-RodriguezG,ManganielloVC,MossJ,VaughanM(2009)
Interactionofphosphodiesterase3AwithbrefeldinA-inhibitedguaninenucleotide-exchangepro-
teinsBIG1andBIG2andeffectonARF1activity.ProcNatlAcadSciUSA106:6158-6163
Rabe KF, Magnussen H, Dent G (1995) Theophylline and selective PDE inhibitors as broncho-
dilators and smooth muscle relaxants. Eur Respir J 8:637-642
Rich TC, Fagan KA, Tse TE, Schaack J, Cooper DM, Karpen JW (2001a) A uniform extracellular
stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc Natl
Acad Sci USA 98:13049-13054
Rich TC, Tse TE, Rohan JG, Schaack J, Karpen JW (2001b) In vivo assessment of local
phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors.
J Gen Physiol 118:63-78
Rich TC, Xin W, Mehats C, Hassell KA, Piggott L, Le X, Karpen JW, Conti M (2006) Cellular
mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma mem-
brane of HEK-293 cells. Am J Physiol Cell Physiol 292:C319-C331
Richter W, Conti M (2002) Dimerization of the type 4 cAMP-specific phosphodiesterases is
mediated by the upstream conserved regions (UCRs). J Biol Chem 277:40212-40221
Richter W, Conti M (2004) The oligomerization state determines regulatory properties and inhibitor
sensitivityoftype4cAMP-specificphosphodiesterases.JBiolChem279:30338-30348
Rocque WJ, Holmes WD, Patel IR, Dougherty RW, Ittoop O, Overton L, Hoffman CR, Wisely
GB, Willard DH, Luther MA (1997) Detailed characterization of a purified type 4 phosphodi-
esterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding. Protein
Exp Purif 9:191-202
Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG,
Beavo JA (1997) Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is
induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.
J Clin Invest 100:2611-2621
Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA (2003) Cyclic GMP phosphodiesterases and
regulation of smooth muscle function. Circ Res 93:280-291
Rybalkina IG, Tang XB, Rybalkin SD (2010) Multiple affinity states of cGMP-specific phospho-
diesterase for sildenafil inhibition defined by cGMP-dependent and cGMP-independent
mechanisms. Mol Pharmacol 77:670-677
Salanova M, Jin SC, Conti M (1998) Heterologous expression and purification of recombinant
rolipram-sensitive cyclic AMP-specific phosphodiesterases. Methods 14:55-64
Saldou N, Baecker PA, Li B, Yuan Z, Obernolte R, Ratzliff J, Osen E, Jarnagin K, Shelton ER
(1998) Purification and physical characterization of cloned human cAMP phosphodiesterases
PDE-4D and -4C. Cell Biochem Biophys 28:187-217
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