Information Technology Reference
In-Depth Information
from Dr J. McLeod and colleagues, UWE, UK), and information presented in
Section 2 (more details found in [4]).
W
ijp
s
DC
ij
W
i
3
p
(
s
DC
i
3
+1)
i
j
=3
o
p
(
m
)=
∗
i
∀
p
=3
|W
ijp
|
i
|W
i
3
p
|
i
j
Table 1.
Examples of weights used for signal processing
w
ijp
j
=1
j
=2
j
=3j= 4
p
=1
2
1
2
1
p
=2
0
0
3
1
p
=3
2
1
-3
1
The tissue has containers for signal and antigen values, namely
S
and
A
.In
the current implementation of the DCA, there are 4 categories of signal (
j
=3)
and 1 signal per category (
i
= 0). The categories are derived from the 4 signal
model of DC behaviour described in Section 2 where:
s
0
,
0
= PAMP signals,
s
0
,
1
= danger signals,
s
0
,
2
= safe signals and
s
0
,
3
= the inflammatory signal. An
antigen store is constructed for use within the tissue cycle where all DCs in the
population collect antigen, which is also introduced to the tissue in an event
driven manner.
The cell cycle maintains all DC data structures. This includes the mainte-
nance of a population of DCs,
DC
m
, which form a sampling set of size
M
.Each
DC has an input signal matrix, antigen vector, output signals, and migration
threshold. The internal values of
DC
m
are updated, based on current data in
the tissue signal matrix and antigen vector. The DC input signals,
s
DC
ij
,usethe
identical mapping for signal categories as tissue
s
ij
and are updated every cell
cycle iteration. Each
s
DC
ij
for
DC
m
is updated via an overwrite every cell cycle.
These values are used to calculate output signal values,
o
p
,for
DC
m
,whichare
added cumulatively over a number of cell cycles to form
o
p
(
m
), where
p
=0is
costimulatory value,
p
= 1 is the mature DC output signal, and
p
=2isthe
semi-mature DC output signal.
3.4
The DCA
The following pseudocode shows the initialisation stage, cycle stage, tissue up-
date and cell cycle.
initialise parameters
{I,J,K,L,M,N,O,P,Q}
while (
l<L
)
update
A
and
S
for
m
=0
to
M
for
0
to
Q
DC
m
samples
Q
antigen from
A
for all
i
=0
to
I
and all
j
=0
to
J
