Biology Reference
In-Depth Information
power and importance of nucleotide sequence databases. The original paper is
Doolittle et al., “Simian Sarcoma Virus.” See also Doolittle, “Some Refl ections.”
50. For a contemporary review of work being done with sequences, see
Gingeras and Roberts, “Steps Toward Computer Analysis.”
51. For instance, in the sample table given here, the exon runs from the
273rd nucleotide to the 286th nucleotide of the listed sequence, and the TATA
box from the 577th to the 595th.
52. Admittedly, this quote is hardly from an unbiased source, since it
formed part of the NBRF's protest against the awarding of the GenBank
contract to BBN and Los Alamos. National Biomedical Research Foundation,
“Rebuttal” [GenBank papers].
53. Schneider, “Suggestions for GenBank” [WBG papers].
54. Los Alamos National Laboratory, “Los Alamos Progress Report,” 1
[GenBank papers].
55. Kabat, “Minutes” [WBG papers].
56. Fickett and Burks, “Development of a Database,” 37 [GenBank
papers].
57. This struggle had become quite public knowledge by 1986. See Lewin,
“DNA Databases.”
58. National Institutes of Health, “Proposed Statement of Work” [Gen-
Bank papers].
59. The discussion of the contractor selection can be found in Kirschstein
and Cassatt, “Source Selection,” 2 [GenBank papers].
60. Robert Cook-Deegan traces the origins further to a meeting in 1984.
See Cook-Deegan, “Alta Summit.”
61. Department of Energy, Offi ce of Health and Environmental Research,
“Sequencing the Human Genome,” 4.
62. National Center for Human Genome Research, “Options for Manage-
ment of Informatics” [GenBank papers]; Jordan, “Record” [GenBank papers].
63. Bolt, Beranek, and Newman, “BBN Progress Report,” 2 [GenBank
papers].
64. Cinkosky et al., “Technical Overview,” 1 [GenBank papers].
65. Cinkosky et al., “Technical Overview,” 2-3 [GenBank papers].
66. Cinkosky and Fickett, “A Relational Architecture” [GenBank papers].
67. Los Alamos National Laboratory, “Database Working Group Meeting”
[GenBank papers].
68. Gilbert, “Towards a Paradigm Shift.”
69. From a review article: Bork et al., “Predicting Function.”
70. A large number of examples can be cited: Mushegian and Koonin,
“Gene Order”; Mushegian and Koonin, “Minimal Gene Set”; R. Himmelreich
et al., “Comparative Analysis”; Koonin et al., “Comparison of Archaeal and
Bacterial Genomes”; Dandekar et al., “Conservation of Gene Order”; Huynen
et al., “Genomics.”
71. National Institutes of Health, National Library of Medicine, “Long
Range Plan,” 27.
72. National Institutes of Health, National Library of Medicine, “Talking
One Genetic Language.”
