Biology Reference
In-Depth Information
6 from LPS-treated macrophages (Pahan
et al.
, 1997).
Other lead
compounds, like
N
-tosyl-L-phenylalanine chloromethyl ketone (
18
),
capsaicin (
19
), and resiniferatoxin (
20
), inhibit the protease(s) that
degrade iκB. Antioxidants such as tetrahydropapaveroline (
21
) and
10,11-dihydroxyaporphine (
22
) inhibit the activation of both
transcription factors AP-1 and NF-κB.
CH
3
O
OH
H
H
O
O
H
3
C
HO
O
O
O
H
3
C
OH
H
H
OH
CH
3
O
O
H
H
H
OH
CH
3
O
okadaic acid (
16
)
O
N
-tosyl-L-phenylalanine
chloromethyl ketone (
18
)
H
3
CO
O
O
H
S
CH
3
O
Cl
H
H
3
C
O
H
3
CO
HO
O
O
CH
3
O
O
NH
2
O
H
3
CO
O
H
3
C
CH
3
O
O
herbimycin A (
15
)
H
H
capsaicin (
19
)
HO
OH
OCH
3
lovastatin (
17
)
O
OH
HO
O
NH
tetrahydropapaveroline (
21
)
O
H
H
H
HO
N
CH
3
OH
O
HO
O
OH
resiniferatoxin (
20
)
10,11-dihydroxyaporphine (
22
)
OCH
3
HO
N
N
N
O
N
N
S
SB210313 (
25
)
N
N
SKF86002 (
24
)
F
F
