Environmental Engineering Reference
In-Depth Information
Fig. 8.5 Plasma etched disposable polyimide microchip for electrospray with integrated 100
μ
m
gold electrodes (courtesy of DiagnoSwiss)
Fig. 8.6 Schematic of the
thin planar polymer chip for
ESI incorporated into the
sandwich holder for
coupling with
MS. Reprinted with
permission from [
30
]
For MS coupling one end of each channel was manually cut in a tip shape, which
was visually inspected with a stereomicroscope. This way, the outlet of the
microchannel is located on the edge of the chip, providing an in-plane electrospray.
Though compatible to automation for high-throughput analysis, these designs
are best suited to act like micrototal analysis systems by integration of other
analytical functions prior to sample delivery to the MS system, such as sample
cleanup, analyte separation by CE, and chemical tagging [
30
]. Moreover, in
