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Key:
Infliximab
Correlation: -0.126
Fluoxetine
Correlation: 0.623
0
20
40
60
80
100
Log10 Statistical Unexpectedness, Uab
Fig. 15.4. Scatterplot of
S
ab
vs.
U
ab
values for two drugs: infliximab (open triangles) and fluoxetine
(solid triangles).
Specifically, Fig. 15.4 shows the suspect fraction
S
ab
plotted against the sta-
tistical unexpectedness
U
ab
for two drugs and the 100 adverse events described
in Sec. 15.6.1. The points represented as open triangles were obtained for the
drug infliximab, while the points represented as solid triangles were obtained for
the drug fluoxetine. The correlations between these two variables are listed in
the lower right of this figure for each drug, and their difference is pronounced:
the correlation for infliximab is
0
.
126, while that for fluoxetine is +0
.
623.The
vertical dashed line at the left end of the plot represents the Bonferroni-corrected
5% significance limit, so only those points to the right of this line are deemed
significant. If we compute the correlations solely from these significant adverse
events, they become
−
0
.
107 for infliximab and +0
.
690 for fluoxetine. While
these results differ slightly in detail, the are qualitatively the same: the degree
of agreement between the subjective association measure
S
ab
and the objective
association measure
U
ab
is much better for fluoxetine than it is for infliximab.
The results shown in Fig. 15.5 demonstrate that this conclusion also holds for
the degree of agreement between the subjective association measure
S
ab
and the
case-specific objective measure
µ
ab
. As noted at the beginning of this section, we
expect a negative correlation between these variables, and this is observed for the
−
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