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Infliximab
Correlation: -0.026
Fluoxetine
Correlation: -0.735
0
5
10
15
Mean Number of Concomitant Medications, Muab
Fig. 15.5. Scatterplot of
S
ab
vs.
µ
ab
values for two drugs: infliximab (open triangles) and fluoxetine
(solid triangles).
drug fluoxetine, where the scatter plot between
S
ab
and
µ
ab
is represented by solid
triangles. The appearance of this scatter plot is consistent with the large negative
correlation of
0
.
735 computed for this drug. The corresponding scatter plot for
the drug infliximab is represented as open triangles and the apparent lack of de-
pendence of
S
ab
on
µ
ab
seen in this plot is consistent with the very small negative
correlation of
−
0
.
026 computed for this drug. These results suggest that, like the
relationship between the subjective measure
S
ab
and the aggregate measures
U
ab
and
R
ab
, the relationship between
S
ab
and the case-specific objective measures
ψ
ab
and
µ
ab
are also strongly drug-dependent.
−
15.6. Clustering Drugs
The observations just presented motivate the following clustering case study. The
goal is to cluster drugs on the basis of the relationships between the subjective and
objective association measures defined and discussed in the preceeding sections of
this paper. Sec. 15.6.1 describes how the drugs and adverse events were selected
for this study, and Sec. 15.6.2 describes the clustering method and validation
approach used to obtain clusters, assess their reasonableness, and determine the
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