Chemistry Reference
In-Depth Information
TABLE 7.15.
(
Continued
)
Reaction
Conditions
Yield
(%)
% ee
(Confi g.)
Catalyst
Ar
R
S
/
C
Reference
trans
- RuCl
2
[(
S
) -
XylBINAP]
[(
S
) - daipen] +
t
BuOK
2 - Thienyl
Me
5,000
i
PrOH,
25 ° C,
8 atm H
2
,
12 h
100
99 (
S
)
297
i
PrOH,
18 - 20 ° C,
5.5 atm
H
2
, 4 h
RuCl
2
[(
R
) -
XylPhanePhos]
[(
S,S
) - dpen] +
t
BuOK
2 - Thienyl
Me
3,000
99
96 (
S
)
59c
RuCl
2
[(
S
) - Xyl - SDP]
[(
S,S
) - dpen] +
t
BuOK
2 - Thienyl
Me
5,000
i
PrOH,
20 - 25 ° C,
50 atm
H
2
, 5 h
98
98 (
S
)
302
2 - Thienyl
Me
4,000
i
PrOH,
25 - 28 ° C,
350 psi
H
2
, 5 h
98.3
132d
RuCl
2
[(
R
) - Xyl - P - Phos]
[(
R,R
) - dpen] +
t
BuOK
>
99.9
trans
- RuCl
2
[(
S
) -
XylBINAP]
[(
S
) - daipen] +
t
BuOK
2 - Pyridyl
Me
5,000
i
PrOH,
25 ° C,
8 atm H
2
,
3 h
100
96 (
S
)
297
RuCl
2
[(
R
) -
XylPhanePhos]
[(
S,S
) - dpen] +
t
BuOK
2 - Pyridyl
Me
1,500
i
PrOH,
18 - 20 ° C,
8 atm H
2
,
18 h
>
99
78 (
S
)
59c
trans
- RuCl
2
[(
S,S
) -
107
]
2
[
t
Bu -
thioethylamine] +
t
BuONa
3,5 - (CF
3
)
2
-
Ph
Me
1,000
n
BuOH,
−
> 99
93 (
S
)
276
10 ° C,
7 atm H
2
,
15 h
trans
- RuCl
2
[(
S
) -
XylBINAP]
[(
S
) - daipen] +
t
BuOK
Ferrocenyl
Ph
2,000
i
PrOH,
28 ° C,
8 atm H
2
,
14 h
100
95 (
S
)
283
i
PrOH,
20 - 25 ° C,
50 atm
H
2
, 5 h
RuCl
2
[(
S
) - Xyl - SDP]
[(
S,S
) - dpen] +
t
BuOK
Ferrocenyl
Me
5,000
100
98 (
S
)
302
RuCl
2
[(
R
) -
XylPhanePhos]
[(
S,S
) - dpen] +
t
BuOK
Ferrocenyl
Me
1,000
i
PrOH,
18 - 20 ° C,
5.5 atm
H
2
, 1 h
> 99
97 (
S
)
59c
