Chemistry Reference
In-Depth Information
TABLE 7.15.
(
Continued
)
Reaction
Conditions
Yield
(%)
% ee
(Confi g.)
Catalyst
Ar
R
S
/
C
Reference
trans
- RuCl
2
[(
R
) - Xyl -
TetraPHEMP]
2
[(
R
) -
daipen] +
t
BuOK
Ph
Me
15,000
i
PrOH,
30 ° C,
10 bar H
2
>
99
98 (
S
)
301
RuCl
2
[(
S
) - Xyl -
HexaPHEMP]
[(
S
) - daipen] +
t
BuOK
Ph
Me
3,000
i
PrOH, rt,
120 psi
H
2
, 20 h
> 99
99 (
R
)
133
[RhCl(cod)]
2
- (
R,S,R,S
) -
Me - PennPhos +
2,6 - lutidine + KBr
Ph
Et
100
MeOH, rt,
30 atm
H
2
, 88 h
95
93 (
S
)
290
trans
- RuCl
2
[(
S
) -
XylBINAP]
[(
S
) - daipen] +
t
BuOK
Ph
Et
2,000
i
PrOH,
26 - 30 ° C,
4 atm H
2
,
15 h
100
99 (
S
)
297
RuCl
2
[(
R
) -
XylPhanePhos]
[(
S,S
) - dpen] +
t
BuOK
Ph
Et
3,000
i
PrOH,
18 - 20 ° C,
5.5 atm
H
2
, 1.5 h
>
99
99 (
R
)
59c
RuCl
2
[(
S
) - Xyl - SDP]
[(
S,S
) - dpen] +
t
BuOK
Ph
Et
5,000
i
PrOH,
20 - 25 ° C,
50 atm
H
2
, 1.5 h
99
99.5 (
S
)
302
trans
- RuCl
2
[(
S
) -
TolBINAP][pica] +
t
BuOK
Ph
TBDMS
10,000
EtOH,
20 - 26 ° C,
10 atm
H
2
, 2.5 h
96
95
273
2 - Furyl
Me
5,000
i
PrOH,
25 ° C,
8 atm H
2
,
12 h
100
297
trans
- RuCl
2
[(
S
) -
XylBINAP]
[(
S
) - daipen] +
t
BuOK
99 (
S
)
RuCl
2
[(
R
) -
XylPhanePhos]
[(
S,S
) - dpen] +
t
BuOK
2 - Furyl
Me
3,000
i
PrOH,
18 - 20 ° C,
5.5 atm
H
2
, 2.5 h
> 99
96 (
S
)
59c
RuCl
2
[(
S
) - Xyl - SDP]
[(
S,S
) - dpen] +
t
BuOK
2 - Furyl
Me
5,000
i
PrOH,
20 - 25 ° C,
50 atm
H
2
, 5 h
99
98 (
S
)
302
RuCl
2
[(
R,R
) - BICP]
(TMEDA) + (
R,
R
) - dpen + KOH
2 - Thienyl
Me
500
i
PrOH,
25 ° C,
60 psi H
2
,
24 h
100
96 (
S
)
46e
