Chemistry Reference
In-Depth Information
Ph
O
N
N
CF
3
S
HN
HN
CF
3
OH
O
147A
(10 mol %)
86-92% ee
91-99% yield
+
NO
2
MeNO
2
Ar
Ar
H
THF, -20°C
16A
23A
148
O
N
N
CF
3
S
HN
HN
O
O
CF
3
SR '
O
SH
O
147B
O
2-step
R'SH
R
N
+
*
O
*
R
N
R
O
O
R' = alkyl
149
150
R=
n
-C
3
H
7
,91%ee
R = alkyl, aryl
87-96% ee
84-99% yield
40B
120
Scheme 2B.32.
S
Ph
CF
3
*
*
Ph
*
*
H
H
1'
1
2
2'
HN
N
S
CF
3
O
O
151
(
1R, 2R, 1'R, 2'R
)
(10 mol %)
NHBoc
NBoc
16:1-99:1 dr
96-99% ee
88-99% yield
NO
2
R'CH
2
NO
2
+
R
Ar
H
CH
3
CN, -20°C, 4ÅMS
R'
23
8A
24
Scheme 2B.33.
