Biomedical Engineering Reference
In-Depth Information
Figure 13.10
Calyx[4]arenas (bellow) and possible type of binding of molecules on the
surface covered by gold and modii ed by dodecanthiol (above).
basis of calyx[4]arenas [54]. Certainly, as it was mentioned above, in this
case the absolute selectivity will be absent but there is possible to obtain
specii c signals by the application of the analysis of the number of the dif-
ferent step of the non-specii c ones by the help of the special computer
program. h e overall view of the calyx[4]arenas and their immobilization
of the gold surface of the transducer through dodecanthiol is shown in
Figure 13.10.
It was analyzed the binding constants of the calyx[4]arenas with some
substances and was shown that they have strong dif erences which have
possibility to discriminate the formed complexes. Of course, it is possible
to synthesis a lot of variants of the calyx[4]arenas which will have much
more dif erences in the ai nity to the separate substances. For the realiza-
tion of the proposed principle there is necessary to use a principle of multi-
parametrical and multi-functional analytical devices.
13.6 Conclusion
Serological investigations have of great practical importance for the pri-
mary screening of a number of biochemical indexes at the dif erent stages
of the diagnostics of pathological states of organism to reveal of a nature of
