Biomedical Engineering Reference
In-Depth Information
CdTe
CdTe
dBSA
Remove Template
Ribind
TEOS
CdTe
CdTe
NH
3
⋅
H
2
O
EtO
EtO
EtO
Si
NH
2
Template
Figure 11.19
Preparative procedures for the fabrication of MIP-coated CdTe QDs as
l uorescent artii cial receptor [Co-opted from reference 46 with permission].
Lyz in real samples. h is l uorescent artii cial receptor may serve as a start-
ing point in the design of highly ef ective synthetic l uorescent receptor for
recognition of target protein.
An improved imprinted i lm-based electrochemical sensor for urea
recognition was developed using CdS QDs doped chitosan as the func-
tional matrix [47]. h e microstructure and composition of the imprinted
i lms depicted by scanning electron microscopy (SEM), attenuated total
rel ection infrared (ATR-IR), X-ray dif raction (XRD), and electrochemi-
cal impedance spectroscopy (EIS) indicated the fabricated feasibility of the
nanoparticle doped i lms via in situ electrodeposition. Dif erential pulse
voltammetric responses under the optimal fabrication conditions showed
that the sensitivity of CdS QDs-MIP electrochemical sensor was enhanced
from the favorable electron transfer and magnii ed surface area of CdS
QDs with a short adsorption equilibrium time (7 min), wide linear range
(5.0×10
-12
to 4.0×10
-10
M and 5.0×10
-10
to 7.0×10
-8
M), and low detection
limit (1.0×10
-12
M). Meanwhile, the fabricated sensor showed excellent
specii c recognition to template molecule among the structural similarities
and coexistence substances. Furthermore, the proposed sensor was applied
to determine the urea in human blood serum samples based on its good
reproducibility and stability, and the acceptable recovery implied its feasi-
bility for practical application.
Following slightly dif erent pathways than other ones Chen
et al.
reported grat ing of molecularly imprinted i lm with diphenolic acid
(DPA) as dummy template molecule on the surface of Mn-doped ZnS QDs
to develop a selective and sensitive sensor for rapid determination of tetra-
bromobisphenol A (TBBPA) in water and soils [48]. h e obtained diphe-
nolic acid-MIP-QDs sensor has distinguished selectivity and high binding
ai nity to TBBPA (Figure 11.20). h e l uorescence quenching fractions
of the sensor presented a satisfactory linearity with the concentrations of
TBBPA in the range of 0.1-100 μM, and its limit of detection can reach
