Biomedical Engineering Reference
In-Depth Information
Figure 11.11
Schematic illustration for the formation mechanism of estriol-MIPs [30].
functional monomer at the silica nanoparticles surface were acted as reac-
tive sites to induce imprinting polymerization (Figure 11.11). h e absorp-
tion capacity results showed that the molecularly imprinted polymers had
an excellent combining ai nity, recognition selectivity and fast kinetics.
Furthermore, the molecularly imprinted polymers were successfully used
as absorbent of dispersive solid-phase extraction coupled with high-per-
formance liquid chromatography to determinate trace estriol and estradiol
in milk tablets. h e high recoveries yielded of 89.1-93.5% were achieved
with the relative standard deviations less than 9.4%. So, the molecularly
imprinted polymers are the ef ective absorbents for the separation and
enrichment of oestrogens in the complex matrices samples.
Similarly, Peng
et al.
reported the preparation of metsulfuron-methyl
(MSM) imprinted polymer layer-coated silica nanoparticles toward analy-
sis of trace sulfonylurea herbicides in complicated matrices [31]. To induce
the selective occurrence of surface polymerization, the polymerizable
double bonds were i rst grat ed at the surface of silica nanoparticles by
the silylation using 3-(Methacryloxy) propyl trimethoxysilane (MPTS)
(Figure 11.12). At erwards, the metsulfuron-methyl templates were
imprinted into the polymer-coating layer through the interaction with
functional monomers (Methacrylic acid, MAA). h e programmed heating
led to the formation of uniform metsulfuron-methyl-imprinted polymer
layer with controllable thickness, and further improved the reproducibility
