Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles - The Chemistry of Molecular Imaging - page 375

Bright eld UCL Overlay

Low

a1 a2 a3

In vivo

b1 b2 b3

In situ

c1 c2 c3

1

4

2 5

6
7

Ex vivo

3

High

fIGure 16.21 In vivo (a), in situ (b), and in vitro (c) upconversion imaging at 10 min. post-injection of AA-Gd-UCNPs. 1, lung; 2,
liver; 3, stomach; 4, heart; 5, spleen; 6, kidney; 7, intestines. Reprinted with permission from Ref. [80]. Copyright 2011 American Chemical
Society.

0.6

R

0.5

NH HN Rotaxane

O -

0.4

N N 0.3

2+

Squaraine

0.2

O -

NH HN

0.1

R

0.0

O

O

400 500 600 700 800 900

Wavelength, nm

Squaraine
+cysteine

Rotaxane
+cysteine

fIGure 16.22 Structure of the squaraine dye. Reproduced from Ref. [81] with permission from the American Chemical Society.