Chemistry Reference
In-Depth Information
(a)
Cy 7 functionalised lipid
RGD functionalised lipid
PAV
DSPC
Soybean oil
PEG-DSPE
Iron oxide nanocrystals
(b)
Soy b.oil
(mg)
PEG-DSPE
(mmole)
DSPC
(mmole)
Mal-PEG-DSPE
(mmole)
PEG:DSPE:Mal
(molar ratio)
PAV
(mg)
FeO
(mg)
CTRL nano
80
0.013
0.013
0.0015
0.013
0.013
0.0138
0.0138
0.0138
0.0138
0.0138
-
-
0.0014
-
-
0.94:1
0.94:1
-
3.75
3.75
-
3.75
-
-
-
7.5
7.5
PAV nano
RGD-PAV nano
80
80
80
80
0.83:1:0.1
FeO nano
0.94:1
0.94:1
PAV+FeO nano
(c)
(d)
50 nm
DLS size (nm) and polydispersity
50 nm
PAV
nano
RGD-PAV
nano
PAV+FeO
nano
FeO
nano
CTRL
nano
50.5 ± 0.14
48.4 ± 0.14
52.5 ± 0.13
50.7 ± 0.15
49.27 ± 0.14
0.137
0.138
0.128
0.150
0.143
O
O
O
HO
H
O
H
H
O
O
fIGure 16.8
(a) Functionalised soybean oil emulsion containing PAV and SPIONs. (b) Structure of prednisolone acetate valerate.
Reproduced from Ref. [41] with permission from the American Chemical Society.
NH
N
N
HN
O
O
HO
OH
OH
O
fIGure 16.9
The macrocyclic structure of chlorin is very similar to that of a porphyrin.
