Biomedical Engineering Reference
In-Depth Information
most enigmatic research questions of bone
biology; and
• Outlining the process of rational tissue design
and optimization by using virtual in silico
models to approach the problem at multiple
length and time scales.
At the risk of exhausting the reader, the only
thing to add is this imperative: “Go forth, fi nd
a collaborator, and model!”
within cortical bone. Adv Heat Mass Transfer Biotech-
nol 40:133-142.
12. Knothe Tate ML, Steck R, Forwood MR, Niederer P
(2000) In vivo demonstration of load-induced fl uid
fl ow in the rat tibia and its potential implications for
processes associated with functional adaptation. J
Exp Biol 203:2737-2745.
13. Lanyon L, Mosley J, Torrance A (1994) Effects of the
viscoelastic behavior of the rat ulna loading model.
Bone 25:383-384.
14. Maurer B, Lehmann C (2006), Die Statik von Knochen.
In: Karl Culmann und die graphische Statik. Zeich-
nen, die Sprache des Ingenieurs. Ernst und Sohn,
Berlin.
15. Meyers JJ, Liapis AI (1998) Network modeling of the
intraparticle convection and diffusion of molecules in
porous particles pack in a chromatographic column.
J Chromatogr A 827:197-213.
16. Mishra S, Knothe Tate ML (2003) Effect of lacunocan-
alicular architecture on hydraulic conductance in
bone tissue: implications for bone health and evo-
lution. Anat Rec A Discov Mol Cell Evol Biol 273:
752-762.
17. Mishra S, Knothe Tate M (2004) Allometric scaling
relationships in microarchitecture of mammalian
cortical bone. 50th Annual Meeting of the Orthopae-
dic Research Society, San Francisco, 29:0401.
18. Niederer PF, Knothe Tate ML, Steck R, Boesiger P
(2000) Some remarks on intravascular and extravas-
cular transport and fl ow dynamics. Int J Cardiovasc
Med Sci 3:21-31.
19. Piekarski K, Munro M (1977) Transport mechanism
operating between blood supply and osteocytes in
long bones. Nature 269:80-82.
20. Qiu S, Rao DS, Palnitkar S, Parfi tt AM (2002) Age and
distance from the surface, but not menopause, reduce
osteocyte density in human cancellous bone. Bone
31:313-318.
21. Qiu S, Rao DS, Paltnitkar S, Parfi tt AM (2002)
Relationships between osteocyte density and bone
formation rate in human cancellous bone. Bone 31:
709-711.
22. Reich KM, Frangos JA (1991) Effect of fl ow on prosta-
glandin E2 and inositol trisphosphate levels in osteo-
blasts. Am J Physiol 261(3 Pt 1):C428-432.
23. Sikavitsas VI, Bancroft GN, Lemoine JJ, Liebschner
MA, Dauner M, Mikos AG (2005) Flow perfusion
enhances the calcifi ed matrix deposition of marrow
stromal cells in biodegradable nonwoven fi ber mesh
scaffolds. Ann Biomed Eng 33:63-70.
24. Sidler H, Steck R, Knothe Tate ML (2006) Site-Specifi c
Porosity and its Impact on Load-Induced Fluid
Movement in Cortical Bone, 52nd Annual Meeting
of the Orthopaedic Research Society, Chicago, 31:
1591.
25. Steck R, Niederer P, Knothe Tate ML (2003) A fi nite
element analysis for the prediction of load-induced
fl uid fl ow and mechanochemical transduction in
bone. J Theor Biol 220:249-259.
26. Steck R, Knothe Tate ML (2005) In silico stochastic
network models that emulate the molecular sieving
characteristics of bone. Ann Biomed Eng 33:87-94.
27. Tami AE, Niederer P, Steck R, Knothe Tate ML (2003)
New insights into mechanical loading behavior of the
ulna-radius-interosseous membrane construct based
on fi nite element analysis of the ulnar compression
References
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Knothe Tate ML (2005) Nano-microscale models of
periosteocytic fl ow show differences in stresses
imparted to cell body and processes. Ann Biomed Eng
33:52-62.
2. Anderson EJ, Savrin J, Cooke M, Dean D, Knothe Tate
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Informatics, Swiss Federal Institute of Technology,
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7. Knothe Tate ML (1997) Theoretical and experimental
study of load-induced fl uid fl ow phenomena in
compact bone. Ph.D. thesis, Mechanical and Biomedi-
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8. Knothe Tate ML (2003) Whither fl ows the fl uid in
bone? An osteocyte's perspective. J Biomech 36:
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11. Knothe Tate ML, Niederer P (1998) A theoretical FE-
based model developed to predict the relative con-
tribution of convective and diffusive transport
mechanisms for the maintenance of local equilibria
