Chemistry Reference
In-Depth Information
Cl
Cl
Cl
1. R
1
X (1.2 equiv)
H
N
H
N
NMe
2
1. R
2
X (1.6 equiv)
PS-BEMP
, rt
N
NR
2
N
N
MeCN, rt
NH
2
NH
2
2. , rt
2. , rt
3. filter
N
N
H
N
R
1
R
1
95-99% yield
86-96% purity
Scheme 6.12
A two-step convenient alkylation of pyrazoles in a one-pot operation