Biomedical Engineering Reference
In-Depth Information
Acknowledgments
The authors would like to thank Drs. Hellmut Merkle, Run-
Xia Tian, Peter Andersen, Gregor Adriany, Pete Thelwall and
Mr. John Strupp for their technical assistance, support and sci-
entific discussion. Part of the reviewed work was supported
by NIH grants of NS41262, EB02632, NS39043, EB00329,
P30NS057091 and P41 RR08079, the W.M. Keck Foundation
and the MIND Institute.
References
1. Boyer PD. What makes ATP synthase spin?
Nature 1999;402(6759):247, 249.
2. Stock
metabolic
rate
in
mammals.
Physiol
Rev
1997;77(3):731-758.
12. Attwell D, Laughlin SB. An energy bud-
get
D,
Leslie
AG,
Walker
JE.
Molec-
ular
architecture
of
the
rotary
motor
in
for
signaling
in
the
grey
matter
of
ATP
synthase.
Science
1999;286(5445):
the
brain.
J
Cereb
Blood
Flow
Metab
1700-1705.
3. Siesjo BK. Brain energy metabolism. New
York: Wiley; 1978. p 101-110.
4. Raichle ME. Circulatory and metabolic cor-
relates of brain function in normal humans.
In: Mountcastle VB, Plum F, Geiger SR,
editors. Handbook of Physiology-The Ner-
vous System. Bethesda: American Physiolog-
ical Society; 1987. p 643-674.
5. Clarke DD, Sokoloff L. Circulation and
energy metabolism of the brain. In: Siegel
GJ, al. e, editors. Basic Neruochemistry:
Molecular,
2001;21(10):1133-1145.
13. Shulman RG, Rothman DL, Hyder F.
Stimulated changes in localized cerebral
energy consumption under anesthesia. Proc
Natl Acad Sci USA 1999;96(6): 3245-3250.
14. Magistretti PJ, Pellerin L, Rothman DL,
Shulman RG. Energy on demand. Science
1999;283(5401):496-497.
15. Wallimann T, Hemmer W. Creatine kinase
in non-muscle tissues and cells. Mol Cell
Biochem 1994;133-134:193-220.
16. Saks VA, Ventura-Clapier R, Aliev MK.
Metabolic control and metabolic capacity:
Two
Cellular
and
Medical
Aspects.
Philadephia:
Lippincott-Raven
Publishers;
aspects
of
creatine
kinase
function-
1999. p 633-669.
6. Shulman RG, Rothman DL, Behar KL,
Hyder F. Energetic basis of brain activity:
Implications for neuroimaging. Trends Neu-
rosci 2004;27(8):489-495.
7. Hyder F, Patel AB, Gjedde A, Rothman
DL, Behar KL, Shulman RG. Neuronal-
glial glucose oxidation and glutamatergic-
GABAergic function. J Cereb Blood Flow
Metab 2006;26(7):865-877.
8. Raichle
ing
in
the
cells.
Biochim
Biophys
Acta
1996;1274(3):81-88.
17. Kemp GJ. Non-invasive methods for study-
ing
brain
energy
metabolism:
what
they
show
and
what
it
means.
Dev
Neurosci
2000;22(5-6):418-428.
18. Shulman RG, Brown TR, Ugurbil K, Ogawa
S, Cohen SM, den Hollander JA. Cellular
applications of
31
Pand
13
C nuclear mag-
netic resonance. Science 1979;205(4402):
160-166.
19. Ackerman JJH, Grove TH, Wong GG,
Gadian DG, Radda GK. Mapping of metabo-
lites in whole animals by
31
P NMR using sur-
face coils. Nature 1980;283:167-170.
20. Lei H, Ugurbil K, Chen W. Measure-
ment of unidirectional Pi to ATP flux in
human visual cortex at 7 Tesla using in
vivo
ME,
Mintun
MA.
Brain
work
and
brain
imaging.
Annu
Rev
Neurosci
2006;29:449-476.
9. Hevner RF, Wong-Riley MT. Regulation of
cytochrome oxidase protein levels by func-
tional activity in the macaque monkey visual
system. J Neurosci 1990;10(4):1331-1340.
10. Hevner RF, Duff RS, Wong-Riley MT.
Coordination of ATP production and con-
sumption in brain: Parallel regulation of
cytochrome oxidase and Na
+
,K
+
-ATPase.
Neurosci Lett 1992;138(1): 188-192.
11. Rolfe DF, Brown GC. Cellular energy uti-
lization and molecular origin of standard
31
P magnetic resonance spectroscopy.
Proc
Natl
Acad
Sci
U
S
A
2003;100:
14409-14414.
21. Gadian DG, Williams SR, Bates TE, Kaup-
pinen RA. NMR spectroscopy: current status
