Chemistry Reference
In-Depth Information
TABLE 5.17
Williams et al. (1982) and Turner et al. (1983) Pearson and Mawby Softness Parameter (
σ
p
) QSARs
Source
QSARs
Cations
r
2
sd
p
n
Williams et al. (1982)
Mouse logLD
50
= 9.56σ
p
−
1.71
Ba
2+
, Be
2+
, Cd
2+
, Co
2+
, Cu
2+
, Hg
2+
, Mg
2+
, Mn
2+
, Ni
2+
, Pb
2+
, Pd
2+
,
Pt
2+
, Sr
2+
, Zn
2+
0.360
0.574
0.05
14
Drosophila
logLC
50
= 9.77σ
p
+
0.0993
Ba
2+
, Be
2+
, Cd
2+
, Cu
2+
, Co
2+
, Hg
2+
, Mg
2+
, Mn
2+
, Ni
2+
, Sr
2+
, Zn
2+
0.503
0.404
0.02
11
Turner et al. (1983)
logLD
50
= 23.1σ
p
−
3.35
Mn
2+
, Co
2+
, Ni
2+
, Cu
2+
, Zn
2+
, Cd
2+
, Hg
2+
, Pb
2+
0.879
0.228
0.001
8
logLD
50
= 15.0σ
p
−
2.56
Mn
2+
, Co
2+
, Ni
2+
, Cu
2+
, Zn
2+
, Cd
2+
, Hg
2+
, Pb
2+
, Mg
2+
, Sr
2+
, Ba
2+
0.588
0.518
0.01
11
logLD
50
= 9.56σ
p
−
1.71
Ba
2+
, Be
2+
, Cd
2+
, Co
2+
, Cu
2+
, Hg
2+
, Mg
2+
, Mn
2+
, Ni
2+
, Pb
2+
, Pd
2+
,
Pt
2+
, Sr
2+
, Zn
2+
0.360
0.574
0.05
14
Source:
Data from M.W. Williams, D. Hoeschele, J.E. Turner, K.B. Jacobson, N.T. Christie, C.L. Paton, L.H. Smith, H.R. Witschi, and E.H. Lee, “Chemical Softness and
Acute Metal Toxicity in Mice and
Drosophila
.”
Toxicol. Appl. Pharmacol.
63 (1982):461-469; and J.E. Turner, E.H. Lee, K.B. Jacobson, N.T. Christie, M.W.
Williams, and J.D. Hoeschele, “Investigation of Correlations between Chemical Parameters of Metal Ions and Acute Toxicity in Mice and
Drosophila
.”
Sci. Total
Environ
. 28 (1983):343-354.