Biomedical Engineering Reference
In-Depth Information
Figure 12.7
Schematic representation of nanoshell based on p-nitrophenyl palmitate-
template constructed onto the surface of iron oxide nanoparticles. (Reproduced from [19].)
Surface molecular imprinting, especially on the surface of silica-modi-
i ed MNPs, has been proposed as a promising strategy for protein recogni-
tion and separation [20]. Inspired by the self-polymerization of dopamine,
Jia
et al.
synthesized a polydopamine-based molecular imprinted i lm
coating on silica-Fe
3
O
4
nanoparticles for recognition and separation of
bovine hemoglobin. Herein, m-MIP having diameter (860 nm) shows a
relatively high adsorption capacity (4.65 ± 0.38 mg g
-1
) and excellent selec-
tivity towards bovine hemoglobin with a separation factor of 2.19. h e
m-MIP with high saturation magnetization (10.33 emu g
-1
) makes it easy
to separate the target protein from solution by an external magnetic i eld.
At er three continuous adsorption and elution processes, the adsorption
capacity of m-MIP remained at 4.30 mg g
-1
. Similarly, a novel superpara-
magnetic surface molecularly imprinted with Fe
3
O
4
@MIP nanoparticles
for water-soluble pel oxacin mesylate was prepared via surface-initiated
