Testicular Xenografting - Male Germline Stem Cells Developmental and Regenerative Potential - page 216

Table 10.2 (continued)

Primate species and
type of grafting

Age of donors and status
of spermatogenesis

Cryopreservation
before grafting

Treatment
of recipient

Status of grafted testicular tissue and
spermatogenic activity in grafted tissue References

Marmoset
(xenologous)

Neonatal No Hormone

injections

- Spermatogonia at 100 days post-grafting

without hormonal stimulation

Schlatt et al.
( 2002 )

- Spermatocytes as most advanced germ cells

at day 135 post-grafting after hormonal
stimulation (Pergonal, 1.5 IU/week for
5 weeks)

Human (xenologous) Fetal (14-20 weeks of

gestation)

No None - After 4-8 weeks survival of the grafted tissue

consisting of primitive Sertoli cells and
gonocyte

Skakkebaek
et al.
( 1974 )

- No germ cell differentiation beyond the

gonocyte stage

- Gonocytes were less frequent in seminiferous

cords from grafts (73-90%) compared to pre-
grafting (99%)