Expression and Manufacture of Pharmaceutical Proteins in Genetically Engineered Horticultural Plants - Transgenic Horticultural Crops: Challenges and Opportunities - page 90

TABLE 4.1
Representative Antibodies, Antibody-Fragments, and Antibody Fusions
Produced in Plants

Antibody
Type

Pharmaceutical
Target

Antigen Crop References

Streptococcal.
surface.antigen.
SA I/II

Secretory.
IgA/G

Tooth.decay N. tobacum [43]

Herpes.simplex.
virus 2

IgG Microbicide.for.

genital.herpes

G. max [59]

glycoprotein.B O. sativa

Tobacco.mosaic.
virus.coat.proteins

Bispeciic-
scFv

Model.bispeciic-
scFv.molecule

N. tobacum [242]

Human.creatine.
kinase-MM

Fab Neurone.and.

rheumatic.diseases

A. thaliana [44]

Human.
carcinoembryonic.
antigen.(CEA)

Diabody Tumor.imaging.for.

colorectal,.lung,.
breast,.and.
pancreatic.
carcinomas

N. tobacum [60]

Human.rhesus.D IgG1 Alloimmunization,.

haemolytic.disease.
of.new.born

A. thaliana [61]

Human.chorionic.
gonadotropin.
(HCG)

scFv,.
diabody.
and.IgG1

Diagnostic.and.
therapeutic.for.
HCG-expressing.
cancers.or.as.
contraceptive

N. tobacum [69]

Tumor.surface.
antigen

scFv Therapeutic.vaccine.

for.NHL

N. benthamiana [66,67]

Rabies.virus IgG Rabies.virus N. tobacum [45]

Herpes.simplex.virus.
glycoprotein.D

LSC.(IgA.
type)

Genital.herpes.
diagnostics

C. reinhardtii [248]

Human.epidermal.
growth.factor.
receptor

IgG Therapeutics.for.

refractory.colorectal.
cancer

Z. mays .(corn.
seeds)

[46]

Hepatitis.B.surface.
antigen

IgG Hepatitis.B.virus.

infections

N. tobacum .
BY2 cells

[62]

Protective.antigen.
(PA).of. Bacillus
anthracis

IgG Therapeutics.for.

anthrax.exposure,.
antiterrorism.agent

N. benthamiana [72]

Lipopolysaccharide.
(LPS).of. S. enterica .
Paratyphi.B

scFv Salmonella enterica .

diagnostic.and.
therapeutic

N. tobacum [48]

Tumor-associate.
antigen.GA733

IgG Colorectal.carinomas N. tobacum [40]