Expression and Manufacture of Pharmaceutical Proteins in Genetically Engineered Horticultural Plants - Transgenic Horticultural Crops: Challenges and Opportunities - page 91

TABLE 4.1 (continued)
Representative Antibodies, Antibody-Fragments, and Antibody Fusions
Produced in Plants

Antibody
Type

Pharmaceutical
Target

Antigen Crop References

Human.epidermal.
growth.factor.
receptor.HER2

scFv Diagnostic.for.breast,.

ovary,.prostate.and.
lung.cancer

N. tobacum [49]

Tetanus.toxin.C.
fragment

RIC Vaccine.for.tetanus.

toxin

N. tobacum [186]

Botulinum.toxin.A scFv Antidote.for.botulinum.

toxin.A,.anti-
bioterrorism.agent

N. tobacum [50]

Tumor-associated.
antigen.
oligosaccharide.
Lewis.Y

IgG2a Breast.and.colorectal.

cancer

N. tobacum [55]

HIV.p24 p24-IgA.

Hc.
fusion

HIV.vaccine N. tobacum [185]

CD30 IgG Immunotherapy.for.

Hodgkin.lymphoma.
(HL).and.anaplastic.
large.cell.lymphoma

Lemna.minor [136]

TGEV Minibody,.

Full.IgA

Therapeutic.for.
TGEV

N. clevelandii [51]

Hepatitis.A.virus scFv-Fc Hepatitis.A.virus.

infection

A. thaliana [54]

Human.epidermal.
growth.factor.
receptor.HER1

scFv Targeting.agent.for.

breast,.ovary,.prostate.
and.lung.cancer

N. tobacum [52]

P. aeruginosa .
serotype.O6ad.PS.
O.side.chain

IgG P. aeruginosa

infection

N. tobacum [39]

HIV.gp.41 IgG HIV.infection N. tobacum .and.

BY2.cell.culture,.
Z. mays

[42,143]

HIV.gp.120 IgG HIV.infection N. benthamiana ,.

Z. mays ,.
A. thaliana

[53,64,134,135]

Ebola.GP1 IgG,.RIC Therapeutic.for.Ebola N. benthamiana [21,263]

West.Nile.Virus.E.
DIII

IgG Therapeutic.for.WNV.

infection

N. benthamiana [58]

Source: . Adapted.from.Chen,.Q.,. Biol. Eng .,.1,.291,.2008..With.permission.
Note: . scFv,.single-chain.variable.fragment;.RIC,.recombinant.immune.complex;.LSC,.large.single.chain.
antibody;.NHL,.non-Hodgkin's.lymphoma.