Chemistry Reference
In-Depth Information
23. Eppelmann K, Doekel S, Marahiel MA. Engineered biosynthesis of the peptide
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24. Mootz HD, Kessler N, Linne U, Eppelmann K, Schwarzer D, Marahiel MA. Decreas-
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deletion in the biosynthetic genes. J. Am. Chem. Soc. 2002;124:10980-10981.
25. Schauwecker F, Pfennig F, Grammel N, Keller U. Construction and in vitro analysis of
a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides.
Chem. Biol. 2000;7:287-297.
26. Stachelhaus T, Schneider A, Marahiel MA. Rational design of peptide antibiotics by
targeted replacement of bacterial and fungal domains. Science 1995;269:69-72.
27. Belshaw PJ, Walsh CT, Stachelhaus T. Aminoacyl-CoAs as probes of condensation
domain selectivity in nonribosomal peptide synthesis. Science 1999;284:486-489.
28. May JJ, Kessler N, Marahiel MA, Stubbs MT. Crystal structure of DhbE, an archetype
for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc.
Natl. Acad. Sci. U.S.A. 2002;99:12120-12125.
29. Eppelmann K, Stachelhaus T, Marahiel MA. Exploitation of the selectivity-conferring
code of nonribosomal peptide synthetases for the rational design of novel peptide
antibiotics. Biochemistry. 2002;41:9718-9726.
30. Grunewald J, Marahiel MA. Chemoenzymatic and template-directed synthesis of
bioactive macrocyclic peptides. Microbiol. Mol. Biol. Rev. 2006;70:121-146.
31. Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT. Peptide cyclization
catalysed by the thioesterase domain of tyrocidine synthetase. Nature 2000;407:
215-218.
32. Sieber SA, Walsh CT, Marahiel MA. Loading peptidyl-coenzyme A onto peptidyl
carrier proteins: a novel approach in characterizing macrocyclization by thioesterase
domains. J. Am. Chem. Soc. 2003;125:10862-10866.
33. Ehmann DE, Trauger JW, Stachelhaus T, Walsh CT. Aminoacyl-SNACs as small-
molecule substrates for the condensation domains of nonribosomal peptide syn-
thetases. Chem. Biol. 2000;7:765-772.
34. Sieber SA, Tao J, Walsh CT, Marahiel MA. Peptidyl thiophenols as substrates for
nonribosomal peptide cyclases. Angew. Chem. Int. Ed. Engl. 2004;43:493-498.
35. Grunewald J, Sieber SA, Mahlert C, Linne U, Marahiel MA. Synthesis and derivatiza-
tion of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. J. Am.
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FURTHER READING
Baltz RH. Molecular engineering approaches to peptide, polyketide and other antibiotics.
Nat. Biotechnol. 2006;24:1533-1540.
Cane DE. Introduction: Polyketide and Nonribosomal Polypeptide Biosynthesis. From
Collie to Coli. Chem. Rev. 1997;97:2463-2464.
Du L, Shen B. Biosynthesis of hybrid peptide-polyketide natural products. Curr. Opin.
Drug Discov. Devel. 2001;4:215-228.
 
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